Share 'Auto Guiding'

Hi Everyone, This is a 2 part question regarding Auto Guiding 1. I have never used guiding before and I would like to start shooting DSO using guiding. How important is it that the guide scope be aligned exactly to the main scope? 2. I am going to use my ZWO ASI120MC or one of my webcams. None of my cameras for guiding have the ST-4 port. Can I run the ST-4 cable directly from my laptop that the…